home
***
CD-ROM
|
disk
|
FTP
|
other
***
search
/
The Arsenal Files 6
/
The Arsenal Files 6 (Arsenal Computer).ISO
/
health
/
med9604b.zip
/
M9640806.TXT
< prev
next >
Wrap
Text File
|
1996-03-04
|
3KB
|
41 lines
Document 0806
DOCN M9640806
TI Opportunistic coccidioidomycosis in patients infected with human
immunodeficiency virus: prevention issues and priorities.
DT 9604
AU McNeil MM; Ampel NM; Emerging Bacterial and Mycotic Diseases Branch,
Centers for; Disease Control and Prevention, Atlanta, Georgia 30333,
USA.
SO Clin Infect Dis. 1995 Aug;21 Suppl 1:S111-3. Unique Identifier :
AIDSLINE MED/96002838
AB Coccidioidomycosis is an uncommon AIDS-defining illness that is endemic
in the southwestern United States. In profoundly immunodeficient
patients infected with human immunodeficiency virus (HIV), the disease
is usually manifest as severe pulmonary infection and is associated with
high mortality. Although diagnosis is often made by routine serological
tests, these appear to be less sensitive than when used for patients who
are not HIV-infected. New ways to diagnose the infection in HIV-infected
patients earlier and with more certainty are urgently needed. The
optimal antifungal regimen for active disease in HIV-infected patients
is currently undefined, but following acute disease in severely
immunocompromised HIV-infected patients (CD4 lymphocyte count, <
200/microL), lifelong systemic antifungal therapy is recommended. The
role of chemoprophylaxis for HIV-infected patients in the area of
endemic disease is also unclear. Improvement of preventive strategies
must await the results of well-designed future studies to determine risk
factors, particularly environmental factors, for development of
coccidioidomycosis and to determine the proportion of disease due to new
vs. reactivated infection. These studies are also needed to elucidate
the role and efficacy of different types of antifungal drug therapies
and the specific dosages useful for prevention, treatment, and long-term
control of these infections.
DE Antifungal Agents/THERAPEUTIC USE AIDS-Related Opportunistic
Infections/EPIDEMIOLOGY/*PREVENTION & CONTROL
Coccidioidomycosis/EPIDEMIOLOGY/*PREVENTION & CONTROL *Health
Priorities Human Incidence Risk Factors United States/EPIDEMIOLOGY
JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).